目的 研究叶穗香茶菜(Isodon phyllostachys)地下部分的化学成分。方法 采用硅胶、葡聚糖凝胶和反相材料色谱法分离纯化，利用现代波谱技术进行结构鉴定。结果 从石油醚部位和乙酸乙酯部位中分离得到14个化合物，分别鉴定为13-羟基-8， 11， 13-三烯-桃柘-19-酸(1)、4-羟基桂皮醛(2)、泡桐素(3)、5，4′-二羟基-6，7，3′-三甲氧基黄酮(4)、7α-羟基谷甾醇(5)、豆甾醇(6)、(E) -2， 5-二羟基桂皮酸(7)、松柏醛(8)、2- -二十烷-12-烯-1， 3， 4-三醇(9)、桦木醇(10)、7α-羟基豆甾醇(11)、熊果酸(12)、胡萝卜苷(13)和齐墩果酸(14)。结论 化合物1～14均为首次从叶穗香茶菜地下部分获得，1～11为首次从该种植物中获得。
Abstract
OBJECTIVE To investigate the chemical constituents of the underground parts of Isodon phyllostachys. METHODS The chemical constituents were isolated by using silica gel, Sephadex LH-20, and RP-18 column chromatographies. The structures of the resulting compounds were elucidated by means of spectroscopic methods. RESULTS Fourteen compounds were isolated from the underground parts of I. phyllostachys, and identified as lambertic acid(1), 4-hydroxylcinnamic aldehyde(2), paulownin(3), 5,4′-dihydroxy-6,7,3′-trimethoxyflavone(4), 7α-hydroxysitosterol(5), stigmasterol(6),(E) -2, 5-dihydroxycinnamic acid(7), coniferyl aldehyde(8), 2-(2′-hydroxydocosanoylamino)-12-eicosene-1,3,4-triol(9), betulin(10), stigmast-5, 22-dien-3β, 7α-diol(11), ursolic acid(12), daucosterol(13) and oleanolic acid(14). CONCLUSION Compounds 1-14 are isolated from the underground parts of I. phyllostachys for the first time, while compounds 1-11 are isolated from this plant for the first time.
关键词
叶穗香茶菜 /
地下部分 /
13-羟基-8 /
11 /
13-三烯-桃柘-19-酸 /
4-羟基桂皮醛 /
泡桐素 /
5 /
4′-二羟基-6 /
7 /
3′-三甲氧基黄酮
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Key words
Isodon phyllostachys: underground part: lambertic acid /
4-hydroxylcinnamic aldehyde /
paulownin /
5,4′-dihydroxy-6,7,3′-trimethoxyflavone
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中图分类号：
R284.2
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参考文献
[1] Flora of China editorial committee of Chinese Academy of Sciences.Flora of China(中国植物志) . Vol 66. Beijing:Science Press, 2004:440.[2] LI W, XIAO C J, HAN B Y, et al. Chemical constituents from the underground parts of Isodon phyllostachys. J Dalian Univ(大连大学学报), 2012, 11(3):12-14. [3] FAN L Y. Studies on the chemical constituents and biological activities of Podocarpus nakaii . Taitung: National Taitung University, 1995.[4] ZHU X L, DOU Y H, HUANG X F, et al. Studies on the chemical constituents of Alpinia Calanga Willd . Mod Chin Med (中国现代中药), 2008, 11(10):13-15.[5] HUANG P, KARAGIANIS G, WEI S X, et al. Chemical constituents in the heartwood of Paulownia Kawakamii . Nat Prod Res Dev (天然产物研究与开发), 2008, 20(2):271-274.[6] OGANESYAN G B. On a flavone from Teucrium orientale . Chem Nat Comp, 2007, 43(4):474-475.[7] MARINA D E, IETROM O, LUCIOP R. Stigmasterols from Typha latzfolza. J Nat Prod, 1993, 53(6):1430-1435.[8] LIU G Y, ZHANG J, YU Z X, et al. Study on sterols and triterpenes from the stems of Akebia quinata . Chin Tradit Herb Drugs (中草药), 2005, 28(12):1060-1062.[9] FENG X Z, XU S X, YAO J, et al. Studies on chemical constituents of Ixeris sonchifolia . Chin Tradit Herb Drugs (中草药), 2001, 32(2):97-99. HERATH H M T B, DASSANAYAKE R S, PRIYADRSHANI A M A, et al. Isoflavonoids and a pterocarpan from Gliricidia. Phytochemistry, 1998, 47(1):117-119. JIANG B. Research advance on chemical constituents and bioactivity for five plants . Kunming:Kunming Institute of Botany Chinese Academy Science, 2001. LIU P, DUAN H Q, PAN Q, et al. Triterpenes from herb of Potentilla chinensis . China J Chin Mater Med (中国中药杂志), 2006, 31(22):1875-1879.
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脚注
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基金
国家自然科学基金资助项目(81060259)
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